The consequences of aneuploidy have traditionally been studied in cell and animal models in which the extrachromosomal DNA is from the same species.Here, we explore a fundamental question concerning the impact of aneuploidy on systemic metabolism using a non-mosaic transchromosomic mouse model (TcMAC21) carrying a near-complete Clippers human chrom
Background: Histological diagnosis of soft tissue sarcomas is a difficult job not only for diverse architecture of different variants Gift Box but also for variability in picture among different parts of a single tumor.Thus, cytodiagnosis of these tumors is one of the most challenging jobs.Aims: To evaluate the role of fine needle aspiration cytolo
Alterations in checkpoint and DNA repair pathways may provide adaptive mechanisms contributing to acquired drug resistance.Here, we investigated the levels of proteins mediating DNA damage signaling and -repair in RPMI8226 multiple myeloma cells and its Melphalan-resistant derivative 8226-LR5.We observed markedly reduced steady-state levels of DNA
Music content annotation campaigns are common on paid crowdsourcing platforms.Crowd workers are expected to annotate complex music artifacts, a task often demanding specialized skills and expertise, thus selecting the right participants is crucial for campaign success.However, there is a general lack of deeper understanding of the distribution of m